• CSO Bio
  • History
  • Publications
  • Patents
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    • Dr. Meckler's Publications:

    1. Meckler, H.; Herr, R. J. Development of the Large-Scale Preparation of 2-(Methanesulfonyl)benzenesulfonyl Chloride Org. Process Res. Dev. 2012, 16, 550−555.

    2. Rainka, M. P.; Dowling, M. S.; King, C.-H. R.; Meckler, H.; Herr, R. J. Efficient Preparation of the 18-Methoxycoronaridine Side-Chain Precursor. Synthesis 2006, 2743-2748.

    3. Coutts, L. D.; DeOrazio, R. J.; Meckler, H. Preparation of 3β-Acetoxy-17a-oxo-androst-5-ene-7,17-dione, a Biologically Active Impurity Isolated from the Production of 3β-Acetoxyandrost-5-ene-7,17-dione. Synthetic Communication 2005, 35, 979-985.

    4. Coutts, L. D.; Meckler, H.; Popp, K. A Simple preparation of N-[2-{(4-propionyl-oxyphenyl)thio}ethyl]propionamide (DIPCAP), a tyrosine-dependent cytotoxic agent as a topical antimelanoma therapy. Synthetic Communications 2004, 34, 2697-2704.

    5. Herr, R. J.; Fairfax, D. J.; Meckler, H.; Wilson, J. D. Preparation of 5-(2-Methoxy-4-nitrophenyl)oxazole: A Key Intermediate for the Construction of VX-497. Org. Proc. Res. Dev. 2002, 6, 677-687.

    6. Coutts, L. D.; Geiss, W. B.; Gregg, B. T.; Helle, M. A.; King, C-H. R.; Itov, Z.; Mateo, M. E.; Meckler, H.; Zettler, M. W.; Knutson, J. C. A Stereospecific Synthesis of 24(S)-Hydroxyvitamin D2, a Prodrug for 1α,24 (S)-Dihydroxyvitamin D2. Org. Proc. Res. Dev. 2002, 6, 246-255.

    7. Herr, R. J.; Vogt, P. F.; Meckler, H.; Trova, M. P.; Schow, S. R.; Petter, R. C. Preparation of 8-Substituted Xanthine CVT-124 Precursor by Late Stage Pyrimidine Ring Closure. J. Org. Chem. 2002, 67, 188-193.

    8. Herr, R. J.; Zhichkin, P.; Hernandez-Abad, P. E.; Meckler, H., Schow, S. R. An Efficient Synthesis of 2-Hydroxyethyl-N,N,N',N',-Tetrakis (2-chloroethyl) phosphorodiamidate. Org. Proc. Res. Dev. 2001, 5, 442-444.

    9. Meckler, H.; Shultis, K. A Formula for Outsourcing Success. Contract Pharm 2000, October, 41-51.

    10. Herr, R. J.; Kuhler, J. L.; Meckler, H.; Opalka, C. J. A Convenient Method for the Preparation of Primary and Symmetrical N,N´-Disubstituted Thioureas. Synthesis 2000, 1569-1574.

    11. Itov, Z.; Meckler, H. A Practical Procedure for the Resolution of (+) and (-)-Tramadol. Org. Proc. Res. Dev. 2000, 4, 291-294.

    12. King, C. H.; Meckler, H.; Herr, R. J.; Trova, M. P.; Glick, S. D.; Maisonneuve, I.M. Synthesis of Enantiomerically Pure (+)- and (-)-18-Methoxycoronaridine Hydrochloride and Their Preliminary Assessment as Anti-Addictive Agents. Bioorg. Med. Chem. Lett. 2000, 10, 473-476.

    13. Herr, R. J.; Meckler, H.; Scuderi, F., Jr. Observed Acidities of Charcoals, Clays and Common Laboratory Purification Reagents in Aqueous and Organic Solutions. Org. Proc. Res. Dev. 2000, 4, 43-45.

    14. Scott, I. L.; Market, R. V.; DeOrazio, R. J.; Meckler, H.; Kogan, T. P. Stereospecific a-Mannosylation. Carbohydr. Res. 1999, 317, 210-216.

    15. Gelotte, K. O.; Mason, D. N.; Meckler, H.; Shieh, W-C.; Starkey, C. M. An Efficient Synthesis of the Novel Triazoloquinazoline Adenosine Antagonist, CGS 15943. J. Heterocyclic Chem. 1990, 27, 1549-1552.

    16. Francis, J. E.; Gorczyca, L. A.; Mazzenga, G. C.; Meckler, H. A Convenient Synthesis of 3,5-Disubstituted-1,2,4-Triazoles. Tetrahedron Lett. 1987, 28, 5133-5136.

    17. Tufariello, J. J.; Meckler, H.; Winzenberg, K. Synthesis of the Lolium Alkaloids. J. Org. Chem. 1986, 51, 3556-3557.

    18. Tufariello, J. J.; Meckler, H.; Senaratne, K. P. A. The Use of Nitrones in the Synthesis of Anatoxin-a, Very Fast Death Factor. Tetrahedron 1985, 41, 3447-3453.

    19. Tufariello, J. J.; Meckler, H.; Senaratne, K. P. A. Synthesis of Anatoxin-a, Very Fast Death Factor. J. Am. Chem. Soc. 1984, 106, 7979-7980.

    20. Ali, Sk. A.; Senaratne, K. P. A.; Illig, C. R.; Meckler, H.; Tufariello, J. J. Nitrone Cycloadditions, Regiochemistry. Tetrahedron Lett. 1979, 4167-4170.